Why is MigraClear™ so Effective?

Doctor Formulation

MigraClear™ is a breakthrough proprietary supplement that effectively combines the most powerful and extensively researched ingredients, giving you an all-in-one solution to get rid of migraines. Every single ingredient in MigraClear was hand-picked by a team of medical doctors and scientific researchers, based on clinical data and designed to help relieve migraines and prevent future attacks, getting results more effectively than any other migraine supplement available.

MigraClear™ contains 11 tested ingredients that meet the strength and purity standards of the USP/NF (United States Pharmacopeia–National Formulary). Each ingredient was carefully researched and included based on clinical data. No other non-prescription solution comes close in terms of quality and purity of ingredients.

Recommended dose: Adults as a dietary supplement for prevention, take 2 (two) capsules daily with meals - 1 (one) in the morning and 1 (one) in the evening. If needed, for an episode, take six (6) daily, 2 in the morning, 2 in the afternoon, and 2 in the evening with food.

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MigraClear™ - Proprietary Blend of Ingredients:

    Magnesium is an essential mineral for over 300 different chemical reactions in the body. Known as the "miracle mineral", it is critical in controlling vasospasms (the contraction and dilation of blood vessels in the brain which occurs during migraines). Individuals who suffer from recurring migraines often have lower magnesium levels. Oral magnesium supplementation has been shown to increase intracellular magnesium levels in people with migraines.
    Many studies have demonstrated the positive effects Magnesium has upon migraine prevention. A 1989 study suggested, "Low brain Magnesium is an important factor in the mechanism of the migraine attack" (Ramadan et al., 1989). Furthermore, some headache patients who use Magnesium report relief from migraines. Authors of a 1996 German study wrote that “high-dose oral Magnesium appears to be effective" in treating migraine (Peikert et al., 1996).

    *References:
  1. J Am Acad Nurse Pract. 2004 Jun;16(6):251-6. Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines. Rios J1, Passe MM.
  2. Headache. 2004 Oct;44(9):885-90. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Maizels M1, Blumenfeld A, Burchette R.
  3. Headache. 1989 Oct;29(9):590-3. Low brain magnesium in migraine. Ramadan NM, Halvorson H, Vande-Linde A, Levine SR, Helpern JA, Welch KM. Cephalalgia. 1996 Jun;16(4):257-63.
  4. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Peikert A1, Wilimzig C, Köhne-Volland R.
  5. Riboflavin appears to have several positive effects on the prevention of migraines. Evidence indicates that impaired mitochondrial oxygen in the brain plays a role in the pathology of migraine headaches. Vitamin B2 (Riboflavin) is essential to tissue respiration and generation of energy metabolism from proteins, carbs and fats.

    Two important randomized, double-blind, placebo controlled trials examined the effect of 400mg of Riboflavin a day for three months on migraine reduction in men and women with a history of recurring migraine headaches. Riboflavin was significantly better than a placebo in reducing attack frequency and number of attacks, especially during the third month of treatment.

    It should also be noted, that Riboflavin can cause the urine to turn a yellow-orange colour. This is nothing to be concerned about, as it is a natural side effect that requires no further action.

    *References:
  6. J Am Acad Nurse Pract. 2004 Jun;16(6):251-6. Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines. Rios J1, Passe MM.
  7. Headache. 2004 Oct;44(9):885-90. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Maizels M1, Blumenfeld A, Burchette R.
  8. Neurology. 1998 Feb;50(2):466-70. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Schoenen J1, Jacquy J, Lenaerts M.
  9. Eur J Neurol. 2004 Jul;11(7):475-7. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study. Boehnke C, Reuter U, Flach U, Schuh-Hofer S, Einhäupl KM, Arnold G.
  10. Feverfew, is a popular herbal remedy often advocated for the reduction of migraines, helps migraines by inhibiting the release of blood vessel dilating substances from platelets and inhibiting the production of inflammatory substances. Numerous double blind placebo controlled trials have been conducted on this herb. Treatment with Feverfew was associated with reduced vomiting and a reduction in the number and severity of attacks in many of these studies. Visual analogue scores also showed an improvement with Feverfew. There are no serious side-effects and no major safety problems.

    *References:
  11. J Am Acad Nurse Pract. 2004 Jun;16(6):251-6. Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines. Rios J1, Passe MM.
  12. Headache. 2004 Oct;44(9):885-90. A combination of riboflavin, magnesium, and feverfew for migraine prophylaxis: a randomized trial. Maizels M1, Blumenfeld A, Burchette R.
  13. Br Med J (Clin Res Ed). 1985 Aug 31;291(6495):569-73. Efficacy of feverfew as prophylactic treatment of migraine. Johnson ES, Kadam NP, Hylands DM, Hylands PJ.
  14. Lancet. 1988 Jul 23;2(8604):189-92. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Murphy JJ1, Heptinstall S, Mitchell JR.
  15. Public Health Nutr. 2000 Dec;3(4A):509-14. The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Ernst E1, Pittler MH.
  16. Butterbur is a potent herb which has been shown effective for reducing migraine headaches. Butterbur's headache-preventive capabilities likely stem from its anti-inflammatory and spasmolytic (muscle-relaxant) effects. It contains active components known as isopetasin, oxopetasin, and petasin, which induce smooth muscle relaxation, particularly in cerebral blood vessel walls. Research indicates that petasin inhibits the proinflammatory lipoxygenase (LOX) enzyme, while both petasin and isopetasin exert highly potent anti-inflammatory effects by inhibiting leukotriene synthesis.

    Butterbur is an herb that naturally contains a toxin called pyrrolizidine alkaloids (PAs). PA's can damage the liver and cause other bodily harm over time. MigraClear™ uses a certified PA free form of Butterbur that completely removes PA's and provides an ultra pure form of this ingredient.

    An important clinical trial conducted by Department of Neurology, Albert Einstein College of Medicine concluded that Butterbur is well tolerated and an effective therapy for migraines. The Department of Neurology, University of Essen, Germany also performed a double-blind and placebo-controlled clinical trial and concluded that migraine attacks could maximally be reduced by 52% in the Butterbur group.

    *References:
  17. J Am Acad Nurse Pract. 2004 Jun;16(6):251-6. Evidenced-based use of botanicals, minerals, and vitamins in the prophylactic treatment of migraines. Rios J1, Passe MM.
  18. Eur Neurol. 2004;51(2):89-97. Epub 2004 Jan 28. The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine. Diener HC1, Rahlfs VW, Danesch U.
  19. Neurology. 2004 Dec 28;63(12):2240-4. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Lipton RB1, Göbel H, Einhäupl KM, Wilks K, Mauskop A.
  20. Headache. 2005 Mar;45(3):196-203. Migraine prevention in children and adolescents: results of an open study with a special butterbur root extract. Pothmann R1, Danesch U.
  21. Niacin is crucial to about 50 chemical reactions in the body. It helps in the release of energy from carbohydrates, fats and cholesterol metabolism and the regulation of blood sugar levels. Niacin sometimes causes a flushing of the face and in the process flushes the migraine away. In one study, 81% of headache sufferers reported positive results when using niacin and in another study 75% had complete headache relief when given Niacin. The migraine formula contains 20 mg of Niacin, which may cause a flushing or "prickly heat" sensation to the face and upper body, usually 15-30 minutes after taking it. However, at a higher dose, there is a common, but harmless, side effect known as the “Niacin Flush.” The skin becomes red, warm and is often accompanied by a burning sensation and occasionally some itching and maybe dizziness. Since Niacin can upset your stomach, you might want to take it with food, and water. Even at high doses, Niacin is safe. Even if the flushing is extreme, though uncomfortable, it will go away and is harmless.

    *References:
  22. Mayo Clin Proc. 2003 Jun;78(6):770-1. Sustained-release niacin for prevention of migraine headache. Velling DA1, Dodick DW, Muir JJ.
  23. Nutr J. 2005 Jan 26;4:3. The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature. Prousky J1, Seely D.
  24. Ginger has been shown to decrease pain and scientists have discovered nine compounds found in ginger which bind to human serotonin receptors, helping to reduce triggers that cause migraines. Also, Ginger has been found effective in multiple studies for treating nausea. Several clinical trials have been performed using Feverfew and Ginger in the treatment of migraines. The conclusion states “Sublingual Feverfew/Ginger appears safe and effective as a first-line abortive treatment for a population of migraineurs who frequently experience mild headache prior to the onset of moderate to severe headache."

    *References:
  25. Headache. 2011 Jul-Aug;51(7):1078-86. doi: 10.1111/j.1526-4610.2011.01910.x. Epub 2011 Jun 1. A double-blind placebo-controlled pilot study of sublingual feverfew and ginger (LipiGesic™ M) in the treatment of migraine. Cady RK1, Goldstein J, Nett R, Mitchell R, Beach ME, Browning R.
  26. T. Mustafa, K.C. Srivastava. Ginger (zingiber officinale) in migraine headache. Journal of Ethnopharmacology, Volume 29, Issue 3, July 1990, Pages 267-273
  27. Ginkgo Biloba is an important antioxidant known for its ability to improve circulation both in the body and brain. One of the most popular herbal remedies in the world, Ginkgo Biloba has been used for migraine headache symptoms and helps to inhibit platelet aggregation.


    *References:
  28. Neurol Sci. 2011 Feb;32(1):79-81. doi: 10.1007/s10072-010-0411-5. Epub 2010 Sep 25. Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study. Esposito M1, Carotenuto M.
  29. Neurol Sci. 2009 May;30 Suppl 1:S121-4. doi: 10.1007/s10072-009-0074-2. Efficacy of Ginkgolide B in the prophylaxis of migraine with aura. D'Andrea G, et al.
  30. Neurol Sci. 2010 Jun;31 Suppl 1:S181-3. doi: 10.1007/s10072-010-0321-6. An innovative approach for migraine prevention in young age: a preliminary study. Usai S1, Grazzi L, Andrasik F, Bussone G.
  31. Wild Yam Root is known to be an anti-inflammatory and antispasmodic agent. Wild Yam Root is used for its ability to aid in managing the equilibrium of hormones as well as its ability to decreases the inflammatory response of the cerebral neurovascular system to abate vasospasm's frequently experienced during a migraine episode.

    *References:
  32. http://www.webmd.com/vitamins-supplements/ingredientmono-970-wild%20yam.aspx?activeingredientid=970&activeingredientname=wild%20yam
  33. Bone K, Mill S, eds. Principles and Practices of Phytotherapy, Modern Herbal Medicine. London: Churchill Livingstone; 2000.
  34. Komesaroff PA, Black CV, Cable V, Sudhir K. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric. 2001;4(2):144-150.
  35. White Willow Bark Extract (Salix Alba) is a natural extract containing the active ingredient called salicin, which is a precursor to aspirin. Salicin is a Cox-1 and Cox-2 inhibitor, which acts as an anti-inflammatory and also reduces pain by inhibiting prostaglandins.

    One recent study indicated that White Willow Bark and Feverfew had a greater effect at reducing migraines than when taken separately. Several countries in Europe including The German Commission and The European Scientific Cooperative on Phytotherapy have approved Willow Bark extract as an analgesic to treat fever and pain.

    *References:
  36. Clin Drug Investig. 2006;26(5):287-96. Tanacetum parthenium and Salix alba (Mig-RL) combination in migraine prophylaxis: a prospective, open-label study. Shrivastava R1, et al.
  37. Chrubasik S. Pain therapy using herbal medicines [abstract]. Gynakologe. 2000;33(1):59-64.
  38. Chrubasik S, Eisenburg E, Balan E, et al. Treatment of low back pain exacerbations with willow bark extract: a randomized double blind study. Am J Med. 2000;109:9-14.
  39. Ernst E, Chrubasik S. Phyto-anti-inflammatories. A systematic review of randomized, placebo-controlled, double-blind trials. Rheum Dis Clin North Am. 2000;26(1):13-27.
  40. Vlachojannis J, Magora F, Chrubasik S. Willow species and aspirin: different mechanism of actions. Phytother Res. 2011;25(7):1102-4.
  41. Bromelain is a natural enzyme that breaks down protein. It's found primarily in pineapples and displays other properties that may help combat certain kinds of headaches, particularly those derived from sinus inflammation or infection.


    *References:
  42. http://www.webmd.com/vitamins-supplements/ingredientmono-895-bromelain.aspx?activeingredientid=895&activeingredientname=bromelain
  43. Guo R, Canter P.H., Ernst E. Herbal medicines for the treatment of rhinosinusitis: a systematic review. Otolaryngol Head Neck Surg. 2006 Oct;135(4):496-506. Review.
  44. Helms S, Miller A. Natural treatment of chronic rhinosinusitis. Altern Med Rev. 2006 Sept;11(3):196-207.
  45. Taussig S.J., Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol. 1998;22:191-203.
  46. Black Pepper (Piperine) is an essential element for increased absorption. Piperine, the main alkaloid from black pepper has been shown to substantially increase the bioavailability of the nutrients in foods and supplements. Piperine can turn a marginally effective therapeutic substance into a highly effective one by increasing its bioavailability and intracellular residency time.

    *References:
  47. http://www.bioperine.com/peer-reviewed-articles.html
  48. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6.
  49. http://bioperine.com/Targeting%20Optimal%20Nutrient%20Absorption%20with%20Phytonutrients.pdf